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[Cancer Research 42, 5084-5088, December 1, 1982]
© 1982 American Association for Cancer Research
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Inhibition of Lung Metastases in Mice Bearing a Malignant Fibrosarcoma by Treatment with Liposomes Containing Human C-reactive Protein

Sharad D. Deodhar1, Karen James, Theresa Chiang, Mark Edinger and Barbara P. Barna

Department of Immunopathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44106 [S. D. D., T. C., M. E., B. P. B.], and Department of Immunology, Rush Presbyterian St. Lukes Hospital, Chicago, Illinois 60612 [K. J.]

Recent studies suggest an immune modulator role for C-reactive protein (CRP). We have tested the effect of CRP in a tumor system designed for study of metastases. Fibrosarcoma T241 was implanted on one hind foot of syngeneic C57BL/6 mice. After 17 days, the tumor-bearing feet were amputated, and i.v. therapy of liposomes containing CRP or control reagents was started. Examination of the lungs on Day 35 showed that CRP:liposome-treated animals had significantly fewer and smaller metastases as compared with those in the control groups. Moreover, 38% of the animals in the former groups were completely free of metastases as compared with 0 to 2% of the controls. Significantly, enhanced survival was also noted in the CRP:liposome-treated group. CRP may have "biological response modifier" function of value in cancer therapy.

1 To whom requests for reprints should be addressed.

Received 5/27/82. Accepted 8/23/82.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1982 by the American Association for Cancer Research.