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Inhibition of Collagen Accumulation by Glucocorticoids in Rat Lung after Intratracheal Bleomycin Instillation¹

College of Medicine, University of Vermont, Burlington, Vermont 05405 [K. M. S., T. D., K. R. C.], and Bristol Laboratories, Syracuse, New York 13201 [A. P.]

Male Fischer 344 rats were given a single lung instillation of bleomycin sulfate (0.6 units/100 g). Some animals were treated 24 hr after bleomycin administration with triamcinolone diacetate. Steroid treatment was continued on alternate days for 4 weeks. At the end of 4 weeks, the lungs of rats receiving bleomycin alone had two-fold increases of both prolyl hydroxylase activity and proteinaceous hydroxyproline as compared to control values. The lungs of bleomycin-treated rats which received 4 mg of triamcinolone diacetate per kg on alternate days had a 33% increase of prolyl hydroxylase activity and a 37% increase of proteinaceous hydroxyproline content as compared to control values. Lung prolyl hydroxylase activity and proteinaceous hydroxyproline content of bleomycin-treated animals receiving glucocorticoid (8 mg/kg) on alternate days were the same as control values. The results indicate that alternate day administration of the synthetic glucocorticoid triamcinolone diacetate blocks lung collagen accumulation following a single intratracheal dose of bleomycin to rats.

¹ Supported by NIH Research Grants HL 14212, HL 23607, and AM 19808.

² Present address: Smith, Kline, and French Laboratories, 1500 Spring Garden Street, Philadelphia, Pa. 15101.

Received 1/ 9/81. Accepted 11/ 2/81.

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