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Effect of the Suspected Tumor Promoters Saccharin, Cyclamate, and Phenol on Nerve Growth Factor Binding and Response in Cultured Embryonic Chick Ganglia¹

Department of Pharmacology and the Cancer Research Center, College of Physicians and Surgeons of Columbia University, New York, New York 10032

The suspected bladder tumor promoters saccharin and cyclamate reversibly inhibited nerve growth factor-induced neurite outgrowth in embryonic chick sensory ganglia, and active concentrations of these artificial sweeteners inhibited binding of ¹²⁵I-labeled mouse submaxillary gland nerve growth factor as well. The skin tumor promoter phenol also reversibly inhibited neurite outgrowth, while comparable concentrations of the nonpromoting but structurally related compounds benzene and fluorobenzene did not. However, in contrast to findings with saccharin and cyclamate, phenol had little, if any, effect on binding of radioactive nerve growth factor.

¹ Supported in part by National Institute of Neurological Communicative Diseases and Stroke Grant RO1 NS 14218 and USPHS Research Career Development Award 1 KO4 NS 00375.

Received 5/11/81. Accepted 10/26/81.

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