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Paradoxical Effect of Radiation on Tumor Incidence in the Rat: Implications for Radiation Therapy¹

Joint Center for Radiation Therapy, Brigham and Women's Hospital, Departments of Radiation Therapy [S. H.] and Medicine [W. C. M.] and New England Deaconess Hospital, Department of Pathology [W. A. M.], Harvard Medical School, Boston, Massachusetts 02115

The high incidence of leukemia in the Fischer rat is reduced by radiation to an incidence below that seen spontaneously. Fractionating the radiation decreased this effect. In contrast, mammary tumors increased with dose until reaching a plateau at the highest doses. Fractionation had little effect. These results are consistent with a hypothesis suggesting that tumor incidence due to radiation is the result of competing processes of tumor induction and cell killing.

¹ Supported in part by Grant CA-10941.

Received 7/ 2/81. Accepted 10/27/81.

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