This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bromer, R. H. Articles by Soares, N. Search for Related Content PubMed PubMed Citation Articles by Bromer, R. H. Articles by Soares, N.

Response of Human Hematopoietic Precursor Cells (CFUc) to Hyperthermia and Radiation

Radiation Oncology Branch, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20205

Currently, whole-body and local hyperthermia is being evaluated in clinical studies as a potential method of cancer treatment. Since the hyperthermic sensitivity of normal human bone marrow cells is not known, we have studied the in vitro response of these cells to two anticancer modalities when administered alone or in combination. Cell survival following various treatment schedules was determined by colony formation of bone marrow cells (CFUc) in soft agar suspensions. Within the survival range studied, a thermal tolerant plateau on the cell survival was not observed for temperatures of 42° or less. However, thermotolerance induction could not be ruled out. In addition, when hyperthermia (42.5° for 1 hr) and radiation (100 rads) were sequenced, the human CFUc survival remained the same regardless of whether the radiation was administered before, during, or after the hyperthermic exposure. Under our experimental conditions, we found the human CFUc to be more radiosensitive (D₀ = 84 rads) than what has been reported previously. The radiation survival response of human CFUc was similar for cells irradiated either in vitro or in vivo. The possible clinical implications for these data are discussed.

¹ Present address: Department of Medical Oncology, Boston Veterans Administration Medical Center, 150 South Huntington Avenue, Boston, Mass.

² To whom requests for reprints should be addressed.

Received 5/14/81. Accepted 1/ 7/82.

This article has been cited by other articles:

				N. Finnberg, U. Stenius, and J. Hogberg Xenobiotics Modulate the p53 Response to DNA Damage in Preneoplastic Enzyme-Altered Foci in Rat Liver; Effects of Diethylnitrosamine and Phenobarbital Toxicol. Sci., March 1, 2000; 54(1): 95 - 103. [Abstract] [Full Text] [PDF]