This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Corbett, T. H. Articles by Schabel, F. M. Search for Related Content PubMed PubMed Citation Articles by Corbett, T. H. Articles by Schabel, F. M., Jr.

Toxicity and Anticancer Activity of a New Triazine Antifolate (NSC 127755)¹

Southern Research Institute, Birmingham, Alabama 35255

A new triazine folate antagonist, 3-chloro-4-{{4-{2-chloro-4-[4,6-diamino-2,2-dimethyl-s-triazin-1(2H)-yl]phenyl}butyl}} benzenesulfonyl fluoride compounded with ethanesulfonic acid (1:1) (NSC 127755), was highly active against four transplantable colon adenocarcinomas (36, 38, 10/A, 12/A) and the Dunning murine ovarian tumor M5076. Treatment schedule studies indicated that a prolonged time of exposure provided optimum antitumor activity for the compound. The combination of NSC 127755 plus 4-amino-1-[5-O-(1-oxohexadecyl)-ß-D-arabinofuranosyl]-2(1H)-pyrimidinone (palmO-ara-C, NSC 135962) was found to have therapeutic synergism against grossly evident colon adenocarcinoma 36.

¹ The work reported herein was supported by Contract NO1-CM-97309 with the Division of Cancer Treatment, National Cancer Institute, NIH, Department of Health and Human Services; by Grant CA 17303 from the National Large Bowel Cancer Project, the University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute; and by grant RO1-CA-26485 from the National Cancer Institute, NIH, Department of Health and Human Services.

² To whom requests for reprints should be addressed.

Received 9/25/81. Accepted 1/20/82.