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Effect of Neoplasms on the Content and Activity of Alkaline Phosphatase and -Glutamyl Transpeptidase in Uninvolved Host Tissues¹

Department of Pediatrics and Pharmacology, Mount Sinai School of Medicine of the City University of New York, New York, New York 10029

In rats carrying s.c. or i.p. neoplasms, there were striking (3- to 20-fold) rises in the -glutamyl transpeptidase and alkaline phosphatase activity of several tissues. These included liver, lung, spleen, bone marrow, and circulating granulocytes but not lymphocytes. In response to mammary carcinoma 5A, for example, the -glutamyl transpeptidase activity changed from 0.27 to 1.18 units/g lung and from 0.3 to 4.0 milliunits/million granulocytes; from 2.3 to 17 units and from 2.4 to 46 milliunits were the accompanying increases in alkaline phosphatase. These abnormalities in each host tissue were reversible in that 3 to 7 days after tumor resection the enzymes returned to control levels.

Among the secondary factors which might have been responsible for the host tissue changes, it was possible to exclude stimulated adrenocortical secretion, tissue necrosis, and transplantation trauma. Comparisons of the effects of two mammary carcinomas, a fibrosarcoma, and two hepatomas on the -glutamyl transpeptidase and alkaline phosphatase of various "noninvolved" tissues indicate that the faster the growth rate of the tumors, the more striking is this host syndrome.

¹ This study was supported by USPHS Grant CA 25005 from the National Cancer Institute.

² To whom requests for reprints should be addressed, at Department of Pediatrics, Mount Sinai Medical Center, Fifth Avenue and 100th Street, New York, N. Y. 10029.

Received 8/24/82. Accepted 2/24/82.