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Estrogen Receptors in Canine Mammary Tumors¹

Departments of Oncology [E. G. M.] and Pathology [A. K. P.], The Animal Medical Center, New York, New York 10021; Cornell University, New York State College of Veterinary Medicine, Ithaca, New York 14853 [H. J. H.], and Baylor College of Medicine, Houston, Texas 77029 [W. B. P.]

The presence of estrogen receptor in 67 canine mammary lesions was correlated with pathological features of the disease. All tissue specimens were analyzed for estrogen receptor content by a sucrose gradient ultracentrifugation method previously used in analyzing human breast cancer cytosols. Pathological features of the tissues were assessed by a veterinary pathologist without knowledge of results of estrogen receptor analysis. Sixty-two (92.5%) of the tissue samples analyzed were classified as epithelial neoplastic lesions, and 38 of these (61.3%), including 24 adenocarcinomas, were estrogen receptor positive (i.e., estrogen receptor concentration equal to or greater than 10 fmol/mg cytosol protein). All five of the nonepithelial neoplastic lesions were estrogen receptor negative.

Canine and human breast cancers share common histological types and have similar biological behavior. If a significant percentage of canine mammary cancer is also estrogen dependent, the dog may be a useful model for hormonal studies and for the development of models of endocrine therapy for human breast cancer.

¹ This work was supported by Grants CA-19072, CA-25586, and CA-26452 from The National Cancer Institute, the Cancer Research Institute, and The Bodman Foundation. A preliminary report of these data was presented at the First International Congress on Hormones and Cancer, October 3 to 6, 1979, at Rome, Italy [S. Iacobelli, R. J. B. King, H. R. Lindner, and M. E. Lippman (eds.), Hormones and Cancer. New York: Raven Press, 1980].

² To whom requests for reprints should be addressed, at The Animal Medical Center; 510 E. 62nd St., New York, N. Y. 10021.

Received 6/18/81. Accepted 3/ 2/82.

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