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DNA Damage in Liver, Kidney, Bone Marrow, and Spleen of Rats and Mice Treated with Commercial and Purified Aniline as Determined by Alkaline Elution Assay and Sister Chromatid Exchange Induction¹

Department of Oncology [S. P., L. S.], Istituto Scientifico per lo Studio e la Cura dei Tumori [M. P., P R., A. Z., A. A., F. V., C. B.], and Department of Physics, Genoa University [M. R. C.], 16132 Genoa, Italy

Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA damage in vivo in liver and kidney of rats. Both the commercial and repurified product are also clearly positive in induction of sister chromatid exchanges in vivo in male Swiss mice bone marrow cells. Liver, kidney, and bone marrow DNA damage was absent in male Swiss mice.

¹ This research was supported by Grants 80.01650.96 and 80.01608.96, from Consiglio Nazionale delle Ricerche Special Research Project "Control of Neoplastic Growth."

² To whom requests for reprints should be addressed.

Received 4/23/81. Accepted 2/10/82.