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Multinucleation in Response to Cytochalasin B: A Common Feature in Several Human Tumor Cell Lines¹

Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk, Virginia 23501

Human tumor cell lines derived from melanoma, glioblastoma, and carcinoma of the prostate, bladder, and kidney multinucleated in response to growth in cytochalasin B-supplemented medium, whereas cell lines derived from normal prostate, kidney, skin, lung, and other nonmalignant diseases remained predominantly binucleate under comparable conditions. The multinucleate cytochalasin B phenotype was dissociable from the anchorage-independent phenotype of tumor cells, suggesting that these markers of cellular transformation are under separate control. These results suggest that uncontrolled nuclear division by tumor cells may be a general marker of abnormal growth or regulation.

¹ This work was supported by Grant CA 28474 awarded by the National Cancer Institute.

² To whom requests for reprints should be addressed.

Received 2/ 8/82. Accepted 3/30/82.