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Activation of Some Aromatic Amines to Mutagenic Products by Prostaglandin Endoperoxide Synthetase

Cellular and Genetic Toxicology Branch [I. G. C. R., E. Z.] and Laboratory of Pulmonary Function and Toxicology [K. S., T. E. E.], National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

² To whom requests for reprints should be addressed, at National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, N. C. 27709.

Cooxidation of xenobiotics may occur during prostaglandin biosynthesis. The ability of prostaglandin endoperoxide synthetase to cooxidize several aromatic amines and other chemicals to mutagenic products was tested with the standard Salmonella tester strains. The microsomal fraction of ram seminal vesicles, a rich source of prostaglandin endoperoxide synthetase, in the presence of the prostaglandin endoperoxide synthetase substrate arachidonic acid metabolized benzidine, 2-aminofluorene, 2-naphthylamine, and 2,5-diaminoanisole to mutagenic products. 1-Naphthylamine, 2-aminoanthracene, 2-acetylaminofluorene, and 2,4-diaminoanisole were negative or weakly mutagenic. N-Nitrosodimethylamine, N-nitrosomorpholine, the pesticide Aminocarb, and di(2-ethylhexyl)phthalate were not activated to mutagenic products by the ram seminal vesicle microsomal fraction.

¹ Present address: Institute of Pharmacology, University of Mainz, D-6500 Mainz, Federal Republic of Germany.

Received 6/ 2/82. Accepted 11/ 2/82.

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