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Effect of Whole-Body Hyperthermia on Cell Survival, Metastasis Frequency, and Host Immunity in Moderately and Weakly Immunogenic Murine Tumors¹

Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

The effects of whole-body hyperthermia (WBH) on animal tumors and on metastasis frequency were studied. The tumors were a chemically-induced fibrosarcoma, FSa-I, which is moderately immunogenic and a spontaneously arisen fibrosarcoma, FSa-II, which is very weakly immunogenic. The WBH was given at 42.5° in an incubator which had an auxiliary heater for accurate temperature control. Animal core temperature reached 41.5° in 30 min. The lung colony assay revealed that the WBH for 60 min given at 24 hr after i.v. injection of single cells gave no lethal damage to either FSa-I or -II tumor cells. A significant inhibition of tumor growth was found when large tumors were given three daily WBH treatments. The frequency of lung metastasis was enhanced when large weakly immunogenic FSa-II tumors were treated by WBH, although no increase in the frequency was observed for FSa-I tumors of any size. Local hyperthermia did not significantly increase the metastasis rate of both tumors. These results suggest that the WBH might be useful for a treatment of large immunogenic tumors. However, the WBH is not a choice of treatment for possible micrometastases.

¹ This work is supported in part by Grants CA26350 and CA13311 from the National Cancer Institute, Department of Health, Education and Welfare.

² To whom requests for reprints should be addressed.

³ Present address: Department of Radiology, Division of Radiation Therapy, University of Utah Medical Center, Salt Lake City, Utah 84112.

⁴ Andre Soriano, Director of Cancer Management, Massachusetts General Hospital.

⁵ Present address: Clinical Radiology, James Graham Brown Cancer Center, Louisville, Ky. 40202.

Received 4/15/81. Accepted 12/ 7/82.

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