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Tumor-localizing Components of the Porphyrin Preparation Hematoporphyrin Derivative¹

Departments of Pharmacology [D. K.] and Oncology [D. K., T-H. C.], Wayne State University School of Medicine, and Harper-Grace Hospitals, Detroit, Michigan 48201

Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This apparent hydrophobicity may derive from hydrogen-bonding phenomena, rather than from absence of hydrophilic functional groups.

¹ Supported by Grant CA 23378 from the National Cancer Institute, NIH, Department of Health and Human Services.

² To whom requests for reprints should be addressed.

Received 7/22/82. Accepted 1/28/83.