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Effects of Four Retinoids in N-Nitrosobis(2-oxopropyl)amine-treated Hamsters¹

Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03756

Four synthetic retinoids were evaluated with regard to chemoprevention of pancreatic carcinomas in carcinogen-treated hamsters. Syrian golden hamsters were given two injections of N-nitrosobis(2-oxopropyl)amine (20 mg/kg) and then were fed retinoid-supplemented diets for 1 year. The incidence of pancreatic carcinomas was lower in six of eight retinoid-fed groups than in the control group, although the differences were not statistically significant. The lowest incidence was observed in groups fed N-(4-pivaloyloxyphenyl)retinamide and N-(2-hydroxypropyl)retinamide. Testicular atrophy with decreased spermatogenesis was noted in males fed N-(2-hydroxypropyl)retinamide, N-(3-hydroxypropyl)retinamide, and N-(2,3-dihydroxypropyl)retinamide.

¹ This work was supported by Contract NO1 CP 85675 from the National Cancer Institute.

² To whom requests for reprints should be addressed.

Received 8/ 9/82. Accepted 4/11/83.