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Regional Measurements of Blood Flow in Experimental RG-2 Rat Gliomas¹

Department of Neurology, Northwestern University, Evanston Hospital, Evanston, Illinois 60201 [D. R. G., J. F. P., J. M. F., N. A. V.]; Membrane Transport Section, Laboratory of Chemical Pharmacology, National Cancer Institute, NIH, Bethesda, Maryland 20205 [R. G. B.]; and the Department of Pathology (Neuropathology), Duke University Medical Center, Durham, North Carolina 27710 [D. D. B.]

Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [¹⁴C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ventricular, and two fourth-ventricular tumors were studied. For all tumors, averaged mean F was 91 ± 33 (S.D.) ml/hg/min. In all but one tumor, mean F was intermediate between normal cortex and corpus callosum values. There was moderate regional variation: averaged mean F was lower in tumor center (78 ± 47 ml/hg/min) than in tumor periphery (93 ± 30 ml/hg/min). Within individual tumors, F showed moderate variation which correlated to some extent with histological features; a regional F of <10 ml/hg/min was observed in only one tumor within an area of necrosis. F in regions of brain immediately surrounding the tumor was higher than in tumor periphery. Blood flow to RG-2 tumors seems unlikely to limit drug delivery any more than to normal brain, and the consistent levels from tumor to tumor and within individual tumors make the RG-2 model an excellent one with which to study drug delivery in experimental brain tumors.

¹ Supported in part by grants from the Boothroyd Foundation, Association for Brain Tumor Research, and the Richard Lilienfeld Memorial Fund.

² Recipient of USPHS Grant NS12745. To whom requests for reprints should be addressed, at Evanston Hospital, 2650 Ridge Avenue, Evanston, Ill. 60201.

³ Recipient of USPHS Grant CA11898.

⁴ Recipient of USPHS Grant NS12745.

Received 8/23/82. Accepted 4/ 5/83.

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