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Toxicity of Methyldopa (Aldomet) to Mouse Neuroblastoma Cells in Vivo¹

Department of Neurology, and the Brain Research Institute, University of Chicago, Chicago, Illinois 60637

The adrenergic blocking agent methyldopa (Aldomet) is toxic to C-1300 neuroblastoma cells in vivo.

Four injections of Aldomet at a dose of 7.5 mg/injection were given over a period of 24 hr to C-1300 neuroblastoma-bearing mice. This treatment killed a significant proportion of the C-1300 neuroblastoma cells. Flow cytometric data suggest that sensitivity of tumor cells to Aldomet is not related to the cell cycle.

¹ Supported by NIH-NINCDS-18413.

² To whom requests for reprints should be addressed, at The University of Chicago, Department of Neurology, 950 E. 59th St., Chicago, Ill. 60637.

Received 5/14/82. Accepted 4/22/83.