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Epidemiology of Coffee and Pancreatic Cancer¹

Division of Epidemiology, Mahoney Institute for Health Maintenance, American Health Foundation, New York, New York 10017

The association between pancreatic cancer and putative risk factors was examined using 275 incident cases and 7994 controls interviewed in six United States cities for a major study of tobacco-related diseases. From the comparison population were excluded patients with other diseases postulated to be associated with pancreatic cancer (e.g., other pancreatic diseases and diseases of the gallbladder) and those admitted for disorders known to be associated with smoking.

After carefully controlling for age, the data failed to indicate an association between coffee consumption and pancreatic cancer (odds ratio 1.0). This was true both before and after adjustment for cigarette smoking and in both males and females. There was a statistically significant association between pancreatic cancer and smoking in both males and females (odds ratio 3.0 for males who smoked more than 1.5 packs/day and 2.0 for females who smoked more than 1 pack/day).

¹ Supported in part by USPHS Contract N01-CP-05684, Grant CA32617 from the National Cancer Institute, and American Cancer Society Special Institutional Grant SIG-8.

² To whom requests for reprints should be addressed.

Received 10/26/82. Accepted 4/21/83.

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