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Sensitivity of Xenografts of Human Pancreatic Adenocarcinoma in Nude Mice to Heat and Heat Combined with Chemotherapy¹

General Motors Surgical Research Laboratory, Department of Surgery [M. H. S., A. C., J. G. F.], and the Human Tumor Cell Laboratory [J. F.], Memorial Sloan-Kettering Cancer Center, New York, New York 10021

The sensitivity of two human pancreatic adenocarcinomas (Capan-1 and Capan-2) to heat and heat combined with chemotherapy was studied using xenografts of the tumors in the foot of athymic nude mice. Heat was applied by immersion of the tumor in a water bath at 43.5° for 1 hr. A single i.p. dose of mitomycin C, cisplatin, 5-fluorouracil, or 0.9% NaCl solution was given at 1 hr prior to treatment. Heat treatment alone significantly suppressed tumor growth (p < 0.001), with 35% of the tumors showing complete regression. Combined treatment using heat plus chemotherapy yielded significantly greater suppression of tumor growth (p < 0.05) with mitomycin for both tumors and with cisplatin or 5-fluorouracil for Capan-1. Combined treatment also gave higher rates of complete tumor regression: 55 and 64%, respectively, for Capan-1 and Capan-2 as compared with 18 and 47% for the respective tumors treated by heat alone. These observations suggest that human pancreatic carcinomas are sufficiently sensitive to heat combined with chemotherapeutic treatment to warrant a clinical trial of these modalities.

¹ This work was supported by grants from the General Motors Corporation and National Cancer Institute (CA-08748). Presented in part at the Surgical Forum, 67th Annual Clinical Congress of the American College of Surgeons, Chicago, Ill., October 1982 (27).

² To whom requests for reprints should be addressed, at Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, N. Y. 10021.

Received 1/18/83. Accepted 5/26/83.

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