This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sumiyoshi, H. Articles by Tahara, E. Search for Related Content PubMed PubMed Citation Articles by Sumiyoshi, H. Articles by Tahara, E.

Effects of Gastrin on Tumor Growth and Cyclic Nucleotide Metabolism in Xenotransplantable Human Gastric and Colonic Carcinomas in Nude Mice¹

Department of Pathology, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734, Japan

This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcinoma). In SC-6-JCK, the treatment with s.c. injection of pentagastrin at a dose of 10 µg/mouse once daily for 25 days promoted the growth of the tumor transplanted in nude mice, but gastrin had no effect at all on St-15 and Co-3. In SC-6-JCK, the weight, size, and labeling index of [³H]thymidine of the tumor were significantly increased in comparison with those of the control (p < 0.05).

In SC-6-JCK, cyclic adenosine 3':5'-monophosphate (cAMP) in the tumor was increased by a single i.p. injection of pentagastrin at a dose of 20 µg/mouse in nude mice, but such an increase was not observed in St-15 and Co-3. Cyclic guanosine 3':5'-monophosphate in SC-6-JCK was slightly increased by gastrin treatment but was not affected in the other tumors. In SC-6-JCK, at 30 min after gastrin treatment when cAMP showed a maximum increase, the activity ratio of cAMP-dependent protein kinase in the tumor was also elevated. In vitro also, gastrin stimulated cAMP production and cAMP-dependent protein kinase activation. The data suggest that some human gastric carcinomas may have receptor for gastrin.

¹ Supported in part by grants-in-aid for cancer research from the Ministry of Education, Science, and Culture (58010070, 58015078).

² To whom requests for reprints should be addressed.

Received 2/22/84. Accepted 6/14/84.

This article has been cited by other articles:

				R. P. Thomas, M. R. Hellmich, C. M. Townsend Jr., and B. M. Evers Role of Gastrointestinal Hormones in the Proliferation of Normal and Neoplastic Tissues Endocr. Rev., October 1, 2003; 24(5): 571 - 599. [Abstract] [Full Text] [PDF]

				A M Smith and S A Watson Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence Gut, December 1, 2000; 47(6): 820 - 824. [Abstract] [Full Text] [PDF]

				A. M. Smith, T. Justin, D. Michaeli, and S. A. Watson Phase I/II Study of G17-DT, an Anti-Gastrin Immunogen, in Advanced Colorectal Cancer Clin. Cancer Res., December 1, 2000; 6(12): 4719 - 4724. [Abstract] [Full Text]

				Y. Konda, H. Kamimura, H. Yokota, N. Hayashi, K. Sugano, and T. Takeuchi Gastrin stimulates the growth of gastric pit with less-differentiated features Am J Physiol Gastrointest Liver Physiol, October 1, 1999; 277(4): G773 - G784. [Abstract] [Full Text] [PDF]

				X. Chen, G.-y. Yang, W. Y. Ding, F. Bondoc, S. K. Curtis, and C. S. Yang An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload Carcinogenesis, September 1, 1999; 20(9): 1801 - 1808. [Abstract] [Full Text] [PDF]

				W F Heydens, A G. Wilson, L D Kier, H Lau, D C Thake, and M A Martens An evaluation of the carcinogenic potential of the herbicide alachlor4 to man Human and Experimental Toxicology, June 1, 1999; 18(6): 363 - 391. [Abstract] [PDF]