This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hall, E. J. Articles by Roizin-Towle, L. Search for Related Content PubMed PubMed Citation Articles by Hall, E. J. Articles by Roizin-Towle, L.

Biological Effects of Heat¹

Radiological Research Laboratory, College of Physicians and Surgeons, Columbia University, New York, New York 10032

The biological effects of heat appear to be favorable for its use to treat cancer. Heat kills cells in a predictable and repeatable way. The age response function complements X-rays in that S-phase cells are most sensitive, and at the same time cells that are at low pH or are nutritionally deprived are also more sensitive. This offers the possibility that cycling tumor cells and quiescent cells that have respired to hypoxia may be more sensitive to heat than are the slowly turning over cells of the normal tissues responsible for late effects. Thermotolerance, in general, represents a problem and a complication in clinical practice but may be exploited to advantage. The interaction of heat with ionizing radiation has been studied extensively and is complex; in general, heat inhibits the repair of both sublethal and potentially lethal X-ray damage, but it is not obvious how to exploit this to advantage. By contrast, the potentiation by heat of the action of chemotherapy agents has been relatively neglected. This is a promising area, since local hyperthermia can "target" drug action in a way not otherwise possible. Heat is a weak mutagen and has not been shown to be a carcinogen; this is a most desirable property at a time of increasing concern for the oncogenic potential of agents used to treat cancer.

¹ Presented at the Workshop Conference on Hyperthermia in Cancer Treatment, March 19 to 21, 1984, Tucson, AZ. This investigation was supported by Grants CA-12536, CA-18506, and CA-35355 awarded by the National Cancer Institute, Department of Health and Human Services, to the Radiological Research Laboratory of Columbia University, and by a grant from the New York Community Trust.