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Glucocorticoid Receptors and Steroid Sensitivity in Normal and Neoplastic Human Lymphoid Tissues: A Review¹

INSERM U7, Physiology and Pharmacology, Hôpital Necker, 161 rue de Sèvres, 75015 Paris, France

The determination of estrogen and progesterone receptors in breast cancer has been shown to be useful in predicting the response to endocrine therapy. Given their well-known inhibitory effects on lymphoid tissue, glucocorticoids have been used widely in the treatment of leukemia. Given these facts, over the last 10 years, several investigators have measured the number of glucocorticoid receptors in normal and neoplastic lymphoid tissue to see whether their number correlated with glucocorticoid responsiveness in vitro or in vivo. No clear correlation could be established between the level of glucocorticoid receptor and the in vitro action of steroids in normal and neoplastic lymphoid tissue. In contrast, attempts to correlate glucocorticoid receptor levels in acute lymphocytic leukemia to in vivo steroid responsiveness and immunological type using the whole-cell-binding assay for receptor determination and selecting the patients according to age and immunological criteria have been more successful.

¹ Part of this work was supported by Grant 76-7-1669 from DGRST, by Grant 58-78-90 from INSERM, and by the National Cancer Institute-INSERM Collaborative Agreement on Hormonal Regulation and Cancer (1976/1977).

Received 5/ 5/83. Accepted 10/ 6/83.

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