This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kleinerman, R. A. Articles by Fraumeni, J. F. Search for Related Content PubMed PubMed Citation Articles by Kleinerman, R. A. Articles by Fraumeni, J. F., Jr.

Diazepam Use and Progression of Breast Cancer

Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20205

The relationship between diazepam and breast cancer was evaluated using data from a case-control study of breast cancer, in which 1075 cases and 1146 controls who were participants in a breast cancer screening program were interviewed. Diazepam use was negatively associated with extent of disease and lymph node involvement, and this effect seemed greatest for long-term users of diazepam. It is not certain to what extent these data reflect an ascertainment bias, an association with the reasons for which the drug was prescribed, or change. Whatever the explanation, the findings do not support a previous contention that diazepam promotes or accelerates breast cancer growth.

¹ To whom requests for reprints should be addressed, at Environmental Epidemiology Branch, Landow 3C-16, National Cancer Institute, Bethesda, MD 20205.

Received 5/16/83. Accepted 11/21/83.

This article has been cited by other articles:

				W. Xia, S. Spector, L. Hardy, S. Zhao, A. Saluk, L. Alemane, and N. L. Spector Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine PNAS, June 20, 2000; 97(13): 7494 - 7499. [Abstract] [Full Text] [PDF]