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Molecular Species of Phospholipid in Rat Hepatomas and in Fetal, Regenerating, and Adult Rat Livers¹

Department of Medical Chemistry [K. S., K. S.] and Third Division of Internal Medicine [T. M., Y. S.], Kansai Medical School, Moriguchi, Osaka 570, Japan

The molecular species of phospholipid in rat hepatomas were found to be different from those in normal adult liver. Phosphatidylcholine in Yoshida hepatoma contained phosphatidylcholine with 34:1 as the sums of the chain length and of the unsaturation of fatty acids esterified at C-1 and C-2 of glycerol, as an example (PC_34:1), PC_36:2, PC_36:1, PC_34:2, and PC_36:3, and its phosphatidylethanolamine contained PE_36:2, PE_36:1, PE_38:4, PE_36:3, and PE_34:1 as major species, whereas phosphatidylcholine in normal adult liver contained PC_38:4, PC_36:2, PC_34:2, PC_36:4, and PC_34:1, and its phosphatidylethanolamine (PE) contained PE_38:4, PE_38:6, PE_40:6, PE_36:4, and PE_36:2, with their level decreasing in that order. While Morris hepatoma also had significantly lower amounts of species containing polyunsaturated fatty acids, there were higher levels of those phosphoglycerides containing monoenoic and dienoic fatty acids. Regenerating liver showed similar patterns of molecular species of both phospholipids to those of normal liver. In contrast, fetal liver had similar molecular species of phosphatidylcholine to those of hepatomas, but had similar species of phosphatidylethanolamine to those of normal and regenerating livers.

¹ This work was presented in part at a satellite symposium of the 12th International Congress of Biochemistry (23). The work was supported in part by Grant-in-Aid for Scientific Research 548127 from the Ministry of Education, Science and Culture of Japan.

² To whom requests for reprints should be addressed.

Received 6/ 7/83. Accepted 1/ 4/84.