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Treatment of Implanted Peritoneal Cancer in Rats by Continuous Hyperthermic Peritoneal Perfusion in Combination with an Anticancer Drug¹

Department of Surgery, Tottori University School of Medicine, 36-1 Nishimachi, Yonago 683, Japan

To study the feasibility of combined hyperthermic and anticancer drug treatment for peritoneal cancer, we devised a continuous hyperthermic peritoneal perfusion system in combination with mitomycin C. The model uses i.p.-transplantable rat ascites hepatoma 100B cells. Hyperthermic peritoneal perfusion alone or combined with mitomycin C was performed after i.p. inoculation of the tumor cells into rats. In rats treated with combined peritoneal perfusion (41.5°) and mitomycin C, the mean survival times were significantly prolonged as compared to those of rats treated with peritoneal perfusion at 41.5° alone. Our results suggest that combined hyperthermic peritoneal perfusion and mitomycin C treatment may represent a therapeutic and prophylactic treatment for peritoneal metastasis after gastric cancer surgery in humans.

¹ Supported by a grant-in-aid for cancer research from the Japanese Ministry of Education and Culture (1981 and 1982).

² To whom requests for reprints should be addressed.

Received 8/31/83. Accepted 2/ 2/84.

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