This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rosenblum, M. G. Articles by Gutterman, J. U. Search for Related Content PubMed PubMed Citation Articles by Rosenblum, M. G. Articles by Gutterman, J. U.

Synergistic Antiproliferative Activity of Leukocyte Interferon in Combination with -Difluoromethylornithine against Human Cells in Culture¹

Department of Clinical Immunology and Biological Therapy, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030

-Difluoromethylomithine, an enzyme-activated irreversible inhibitor of omithine decarboxylase, was administered in combination with human leukocyte interferon to human lymphoblastoid (Daudi) cells in culture. True synergistic antiproliferative activity was observed at 72 hr after continuous exposure. This effect was observed regardless of the ratio of interferon to -difluoromethylornithine concentrations. Although the mechanisms by which this effect occurs are unknown, these studies provide a rationale for combination clinical trials of -difluoromethylornithine with leukocyte interferon.

¹ Research conducted in part by the Clayton Foundation for Research.

² Senior Clayton Foundation Investigator.

Received 11/ 3/83. Accepted 3/ 2/84.