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Circulating Immune Complexes in Rats Bearing 6-Thioguanine-resistant Variants of the 13762 Mammary Adenocarcinoma¹

Department of Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W0 [D. B. S. H., B. Z.], and Department of Experimental Pathology, John Curtin School of Medical Research, Canberra A.C.T., Australia [I. R.]

The relationship between immune complex (IC) formation and tumor cell metastatic potential was investigated in rats inoculated in the footpad with parental 13762 mammary adenocarcinoma cells or 6-thioguanine-resistant (TGR) variant cells. These cell lines are either highly metastatic (13762), nonmetastatic (TGR), or occasionally metastatic (TGRrev, TGRrevM). The 13762 TGR rat tumor model thus provides the opportunity to examine host immune responses to tumor cells of different phenotypes, but derived from the same parent tumor line. IC levels were low in 13762 tumor-bearing rats. In contrast, animals with TGR tumors had high levels of ICs in their sera, while animals bearing TGRrev and TGRrevM tumors had intermediate levels of ICs. In this rat tumor model system, IC formation is inversely related to the metastatic potential of the tumor lines.

¹ This research was supported by an Operating Grant from the National Cancer Institute of Canada.

² Recipicient of a Saskatchewan Health Research Board Student Fellowship. Present address: Department of Surgery, Division of Oncology, 54–140 CHS, UCLA School of Medicine, Los Angeles, CA 90024.

³ Recipient of a Development Grant from the Medical Council of Canada. To whom requests for reprints should be addressed.

Received 8/29/83. Accepted 3/ 6/84.

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