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Differential Expression of Intermediate-Filament Proteins in Murine Sarcoma 180 Ascites or Solid Tumor

Institute of Experimental Pathology, German Cancer Research Center, Im Neuenhelmer Feld 280, D-6900 Heidelberg, Federal Republic of Germany [A. G., H. W., J. S., M. V.], and Department of Pathology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812, Japan [M. K.]

The intermediate-filament proteins in Sarcoma 180 ascites cells and solid tumors generated by s.c. injection of ascites cells in NMRI or nude mice were analyzed by one- and two-dimensional gel electrophoresis and identified by immunological methods. The ascites form of Sarcoma 180 coexpresses keratin and vimentin, whereas the solid tumor ceases to synthesize keratins but continues to express vimentin. These reversible changes in the expression of intermediate-filament proteins may be due to a change in the differentiation program induced by environmental conditions like growth with or without cell contact.

¹ To whom requests for reprints should be addressed.

Received 8/25/83. Accepted 2/28/84.

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