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Differential Effects of Surgical Suture Materials in 1,2-Dimethylhydrazine-induced Rat Intestinal Neoplasia¹

Department of Medicine (Gastroenterology), University of British Columbia Faculty of Medicine and Cancer Research Center, Vancouver, British Columbia V6T 1W5, Canada

The incidence, distribution, size, and histopathology of rat small and large bowel tumors induced by sequential administration of 1,2-dimethylhydrazine followed by cecal placement of one of six differing types of suture materials were systematically examined. In addition, measurements of ß-glucuronidase activities in large bowel contents followed by fecal trace metal determinations were done. The results indicate that specific slowly absorbed and nonabsorbable suture materials in the absence of a surgical anastomosis promote tumor induction locally in the rat cecum. In addition, cecal suture material composed of multifilament stainless steel wire enhanced tumor development at a "downstream" site in the distal colon, paralleling increased fecal ß-glucuronidase activities at this site and implicating a possible luminally mediated mechanism for colon tumor development in this animal model.

¹ Supported by the National Cancer Institute of Canada and the Canadian Foundation for Ileitis and Colitis.

² Recipient of Research Grant MA 6918 from the Medical Research Council of Canada. To whom requests for reprints should be addressed, at Gastroenterology, ACU F-137, U. B. C. Health Sciences Center Hospital, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada.

Received 4/26/83. Accepted 4/ 2/84.