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Genotoxicity of a Variety of Mycotoxins in the Hepatocyte Primary Culture/DNA Repair Test Using Rat and Mouse Hepatocytes¹

Departments of Pathology [H. M., F. O., T. K.] and Biochemistry [K. K.], Gifu University School of Medicine, Gifu 500, Japan; Research Institute for Chemobiodynamics, Chiba University, Chiba 280, Japan [M Y.]; Faculty of Agriculture, Tottori University, Tottori 680, Japan [T. H.]; and Naylor Dana Institute, American Health Foundation, Valhalla, New York 10595 [G. M. W.]

Twenty-eight mycotoxins were studied in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6-dimethoxysterigmatocystin, versicolorins A and B, averufin, xanthomegnin, luteosporin, and chrysazin, as well as by the carcinogenic myocotoxins, aflatoxin B₁, sterigmatocystin, luteoskyrin, ochratoxin A, azaserine, mitomycin C, and actinomycin D. The positive results with compounds of unknown carcinogenicity suggest that they are possibly genotoxic carcinogens. The carcinogenic mycotoxins, penicillic acid, patulin, griseofulvin, and rugulosin, which did not elicit repair synthesis may be nongenotoxic carcinogens.

¹ This work was supported by a grant-in-aid for cancer research from the Ministry of Education, Science, and Culture, Japan.

² To whom requests for reprints should be addressed.

Received 11/22/83. Accepted 4/11/84.

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