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Regulation of Acetylcholinesterase Expression in the K-562 Cell Line¹

Department of Biology, I.S.M.I., University of Genoa, 16132 Genoa, Italy

Acetylcholinesterase, an erythroid marker constitutively expressed in K-562 cells, can be further induced by sodium butyrate. The highest level of acetylcholinesterase induction is reached in 3 days, in parallel with increased hemoglobin expression. Acetylcholinesterase induction is reversible, and repeated addition of butyrate is necessary to maintain a high level of the enzyme. Actinomycin D inhibits the induction.

¹ This work was supported by CNR Grant 82.00212.96, Progetto Finalizzato Controllo della Crescita Neoplastica, and by CNR Grant 156 CT/81.00076.04.

² To whom requests for reprints should be addressed, at Department of Biology, I.S.M.I., University of Genoa, Viale Benedetto XV, 6, 16132 Genoa, Italy.

Received 10/17/83. Accepted 5/23/84.