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Immunogenicity and Immunosensitivity of a Guinea Pig B-Cell Leukemia Subline Lacking Cell Surface Ia Antigens

Laboratory of Immunobiology, National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland 21701

L2C is a transplantable B-cell leukemia of strain 2 guinea pigs. Transplantation protection experiments were performed with L2C sublines expressing or lacking cell surface antigens coded for by the I region of the major histocompatibility complex (Ia). A subline (BZ-L2C) that lacked cell surface Ia antigens was immunogenic but relatively resistant to immunological attack. The data suggest that rejection of this B-cell leukemia may be influenced by expression of cell surface Ia antigens.

¹ To whom requests for reprints should be addressed.

Received 7/ 5/84. Accepted 9/26/84.