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Inhibition of 7,12-Dimethylbenz(a)anthracene-induced Skin Papillomas and Carcinomas by Dehydroepiandrosterone and 3-ß-Methylandrost-5-en-17-one in Mice¹

Fels Research Institute [L. L. P., G. C. H., A. G. S.] and Departments of Pathology [G. C. H.], Family Practice [E. L. S.], and Microbiology [A. G. S.], Temple University Medical School, Philadelphia, Pennsylvania 19140, and Department of Chemistry [R. J. R., J. R. W.], Temple University, Philadelphia, Pennsylvania 19122

Topical application of the adrenal steroid, dehydroepiandrosterone, or the synthetic steroid, 3-ß-methylandrost-5-en-17-one, which unlike dehydroepiandrosterone is not demonstrably uterotrophic, inhibits 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas in the CD-1 mouse.

¹ This work was supported by Grant CA-12227 from NIH, Cancer Prevention Grant SIG-6 from the American Cancer Society, the National Foundation for Cancer Research, and the Samuel S. Fels Fund.

² To whom requests for reprints should be addressed.

Received 5/17/84. Accepted 9/25/84.

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