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Induction by X-Irradiation of Adenosine Triphosphatase-deficient Islands in the Rat Liver and Their Characterization¹

Department of Pathology, Cancer Institute, Tokyo 170 [T. K., K. N.] and Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba 260 [S. S.], Japan

The potential of X-rays to induce preneoplastic lesions in the rat liver was studied in order to clarify the reason why X-rays are ineffective in inducing hepatocellular carcinoma in this animal. Male newborn rats at 8 or 22 days of age received whole body X-ray irradiation of 100 to 400 rads. After weaning they were fed either basal diet or a diet containing 0.05% phenobarbital as a promoter. X-rays induced numerous adenosine triphosphatase-deficient islands appearing in the liver by wk 22 of age. However, they were generally small, -glutamyl transpeptidase-negative, and did not clearly respond to the promoting stimulus of phenobarbital. No hepatic tumors were observed by 22 mo after radiation, even in phenobarbital-treated animals. Thus the X-ray-induced enzyme-altered islands differ somewhat qualitatively from those induced by potent hepatic carcinogens and their preneoplastic potential if at all present may be very low. Similarities between these X-ray-induced lesions and some types of spontaneous enzyme-altered islands are pointed out.

¹ Supported by a grant-in-aid for Cancer Research from the Ministry of Education, Science, and Culture of Japan.

² To whom requests for reprints should be addressed.

Received 10/ 9/84. Revised 8/27/85. Accepted 8/29/85.

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