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Effect of Cyclophosphamide on Friend Virus Leukemogenesis in Virussensitive and Virus-resistant Mice¹

Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212

The influence of cyclophosphamide (CY) on Friend virus leukemogenesis was studied in SJL/J, C57BL/10J, and C57BL/10J x SJL/J F₁ (hereafter called B10SJF₁) mice. All three differ in their susceptibility to the viral oncogenic effect. Immunosuppressive doses of CY, which by themselves produced no cancer, were followed 2 days later by injection of Friend leukemia virus. The virus doses were the same as used previously. Although in other experiments preinjection of various chemical carcinogens augmented leukemogenesis by Friend leukemia virus in SJL/J mice, in the present study, pretreatment by CY had no such effect. In contrast, CY increased Friend erythroleukemia incidence from 15 to 100% in B10SJF₁ mice and from 0 to 85% in C57BL/10J mice. The disease in C57BL/10J mice had a 190-day incubation period, which is approximately 5 times that in the SJL/J and B10SJF₁ mice. During this latent period, the C57BL/10J mice harbored infectious Friend leukemia virus in their plasma.

¹ This work was supported by Department of Energy Contract De-AC02-78EVO 4800.A003.

² To whom requests for reprints should be addressed.

Received 8/ 3/84. Accepted 11/ 1/84.