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Intercellular Communication Capacity as a Possible Determinant of Transformation Sensitivity of BALB/c 3T3 Clonal Cells¹

International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon 08, France [H. Y., T. E.]; Hiroshima University School of Dentistry, Kasumi-cho, Minami-ku, Hiroshima, Japan [T. E., Y. S., Y. K.]; National Cancer Institute, NIH, Bethesda, Maryland 20205 [T. K.]

While clonal cell variants of BALB/c 3T3 with high and low susceptibilities to ultraviolet radiation- and benzo(a)pyrene-induced transformation show similar intercellular communication capacities when they are in the growing phase, a significant loss in communication occurs at confluence only in transformation-sensitive clonal variant cells. A potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, which also enhances BALB/c 3T3 cell transformation induced by methylcholanthrene, inhibited intercellular communication of these variants to a similar extent. These results suggest that intrinsic differences in the control of intercellular communication may be a determinant of the susceptibility of these variants to the induction of transformation.

¹ Part of this work was presented at the 75th Annual Meeting of the American Association for Cancer Research (22).

² To whom requests for reprints should be addressed.

Received 7/31/84. Accepted 10/16/84.