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Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines¹

Department of Oncology, University of Miami Medical School, and the Comprehensive Cancer Center for the State of Florida, Miami, Florida 33136

Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cells. Multiparametric flowcytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G₂/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.

¹ These studies were supported by NIH Grant CA-23960 from the National Cancer Institute.

² To whom requests for reprints should be addressed, at Cancer Center, R-71, P. O. Box 016960, Miami, FL 33101.

Received 4/ 9/84. Accepted 11/15/84.

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