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Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose¹

Preclinical Screening Laboratory, Program Resources, Incorporated [J. E. T., J. A., H. P., M. C., B. L., M. S.], and Biological Response Modifiers Program [M. C.], National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland 21701

The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(I,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(I,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(I,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a debulking regimen it resulted in increased survival with protocols in which poly(I,C)-LC alone was insufficient. These data suggest that the systemic administration of poly(I,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.

¹ Research sponsored by the National Cancer Institute, Department of Health and Human Services, under Contract N01-23910 with Program Resources, Inc.

² To whom requests for reprints should be addressed, at Preclinical Screening Laboratory, Program Resources, Inc., NCI-Frederick Cancer Research Facility, P. O. Box B, Frederick, MD 21701.

Received 5/ 7/84. Accepted 11/26/84.