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Effects of Total-Body Hyperthermia on Metastases from Experimental Mouse Tumors¹

First Department of Surgery, Tottori University School of Medicine, 36-1 Nishi-machi, Yonago 683, Japan

To study the effects of total-body hyperthermia (TBH) on metastases from malignant tumors, Lewis lung carcinoma (LLC)-bearing C57BL/6 mice and mouse ascites hepatoma 134-bearing C3H/He mice were immersed in a heated water bath. Rectal temperature was maintained for 30 min at 40 °C or 42 °C. After treatment, the incidence of lung metastasis was analyzed in LLC-inoculated mice, and the presence or absence of metastasis in affiliated lymph nodes was determined in mouse ascites hepatoma 134-inoculated mice. A significant inhibition in primary tumor growth in LLC- and mouse ascites hepatoma 134-bearing mice treated with 42 °C TBH was noted. The incidence of lung metastasis was increased from the control level of 1.6 ± 0.63 (SD) to 2.4 ± 0.98 in the 42 °C TBH (P < 0.01) groups but not in the 40 °C TBH group. Metastasis to affiliated lymph nodes was similar for the controls and the 40 °C and 42 °C TBH groups. The increase in lung metastasis in LLC-treated mice subjected to 42 °C TBH could be prevented by the combined use of anticancer drugs such as cis-diamminedichloroplatinum(II) (1.0, 3.0 mg/kg) or mitomycin C (0.3, 1.0 mg/kg). Furthermore, the combined use of 42 °C TBH and anticancer drugs showed the inhibition of primary tumor growth to a greater degree than did 42 °C TBH alone or anticancer drugs alone. Since 42 °C TBH may induce tumor metastasis, especially hematogenous metastasis, it seems advisable to use anticancer drugs in combination with clinical thermal applications.

¹ Supported by a grant-in-aid for cancer research from the Japanese Ministry of Education and Culture (1982, 1983).

² To whom requests for reprints should be addressed.

Received 7/ 2/84. Revised 12/26/84. Accepted 12/28/84.

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