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Vascular Resistance Characteristics of 7,12-Dimethylbenz(a)anthracene-induced Rat Mammary Tumors and Normal Tissues as Studied in Vitro¹

Departments of Physiology [L. W.], Surgery I [L. W., E. T.], and Histology and Oncology [R. H.], University of Göteborg, Box 33031, S-400 33 Göteborg, Sweden

Vascular perfusion characteristics have been studied in dimethylbenz(a)anthracene-induced rat mammary neoplasia and compared with those of skin, skeletal muscle, salivary gland, kidney, spleen, uterus, and brain by means of an artificial perfusion technique. Perfusion of tissues and organs was measured by the microsphere tracer technique. This procedure makes possible a detailed hemodynamic analysis of several tissues under controlled conditions, in this study maximum vascular relaxation, without confounding endogenous vasoregulation.

The maximal perfusion capacity, i.e., during smooth muscle relaxation, of tumors and various tissues was related to perfusion pressure at three levels by means of three differently labeled microspheres. Tumors, especially large ones, have a low maximum perfusion capacity, i.e., high vascular resistance, compared to most other tissues. For the tumors, a relatively high perfusion pressure is required to open up the otherwise collapsed vascular network.

¹ This investigation was supported by grants from the Swedish Cancer Society (1193-B83-05X) and the Swedish Medical Research Council (B84-12X-06820-01A).

² To whom requests for reprints should be addressed.

Received 10/ 3/84. Revised 2/25/85. Accepted 3/ 5/85.