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Amplification of the Antitumor Activity of Phleomycins and Bleomycins in Rats and Mice by Caffeine

CSIRO Division of Molecular Biology, P. O. Box 184, North Ryde, New South Wales, 2113, [T. E. A., N. A. A., G. W. G.]; CSIRO Division of Mathematics and Statistics, P. O. Box 218, New South Wales, Lindfield, 2070 [R. J. C.]; CSIRO Division of Applied Organic Chemistry, Box 4331, G. P. O., Melbourne, Victoria 3001 [N. K. H., J. A. L.]; and CSIRO Division of Food Research, P. O. Box 52, North Ryde, New South Wales, 2113 [A. L.], Australia

While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying Walker 256 carcinosarcoma and/or mice carrying Ehrlich ascites tumor, even at doses of phleomycin and bleomycin below the minimum effective level. Positive but less conclusive results were also obtained with PLM-A₄A₄G and PLM-G.

¹ To whom requests for reprints should be addressed.

Received 3/26/84. Revised 12/26/84. Accepted 2/ 1/85.