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Transplantation of Human Renal Carcinomas into Athymic Mice¹

Departments of Surgery (Urology) and Radiology, Washington University School of Medicine, St. Louis, Missouri 63110 [R. V. C., A. B.], and Departments of Surgery (Urology) [R. S. F.] and Pathology [C. L.], Veterans Administration Medical Center, Minneapolis, Minnesota 55417

Thirty-one primary human renal carcinomas were transplanted into athymic mice of which ten produced tumors in the mouse host. Only tumors with a nuclear grade of 3 or 4 were successfully transplanted. The nuclear grades of the human tumor and transplant were similar; however, the cellular histology often varied. Patient prognosis appeared to be inversely related to successful tumor transplantation. In the transplant group, the 1-year survival was 30% in contrast to a 1-year survival of 83% among patients with renal cancers of similar stage and grade which did not produce tumors in the mice.

¹ This work was supported by the Veterans Administration Merit Review Grant and the Minnesota Medical Foundation.

² To whom requests for reprints should be addressed, at Division of Urologic Surgery, Washington University School of Medicine, 4960 Audubon Avenue, St. Louis, MO 63110.

Received 10/ 9/84. Revised 2/18/85. Accepted 2/21/85.