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Radiosensitization Effects of Nicotinamide on Malignant and Normal Mouse Tissue¹

Departments of Oncology [G. G. J., E. K.] and Pathology [R. C.], University Hospital, S-221 85 Lund, and Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, Box 7031, S-220 07 Lund [G. G. J., E. K., R. W. P.], Sweden

Inhibitors of the chromatin-associated enzyme adenosine diphosphate ribosyltransferase have been found to inhibit DNA strand rejoining and to potentiate lethality of DNA-damaging agents both in vivo and in vitro. We have in this work examined the radiosensitizing potential of one such inhibitor, nicotinamide, on tumor tissue by using transplanted C3H mouse mammary adenocarcinomas and on normal tissue in a tail-stunting experiment using BALB/cA mice. Our data indicate a radiosensitizing effect of nicotinamide on tumor cells as well as on normal tissue. The data indicate a possible role of adenosine diphosphate ribosyltransferase inhibitors as a sensitizing agent in the radiotherapy of malignant tumors.

¹ This study was supported by grants from John and Augusta Persson's Fund for Medical Scientific Research at the University of Lund and from the Swedish Cancer Society.

² To whom requests for reprints should be addressed, at Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, Box 7031, S-220 07 Lund, Sweden.

Received 12/11/84. Revised 4/10/85. Accepted 4/15/85.