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Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada [R. N. B., R. P.], and Cancer Center, University of Arizona, Tucson, Arizona 85721 [J. M. T.]
We describe the derivation of three human ovarian carcinoma cell lines and the comparison of their properties with two previously described cell lines of like histology (SKOV-3 and CAOV-3). Two of the new lines (HOC-1 and HOC-7) were derived from separate ascites tumors (at 9-month intervals) of a patient with well-differentiated serous adenocarcinoma of the ovary. The third new line, HEY, was derived from a human ovarian cancer xenograft (HX-62) originally grown from a peritoneal deposit of a patient with moderately differentiated papillary cystadenocarcinoma of the ovary. The cell lines demonstrated differential ability to grow in semisolid culture and as xenografts in immunologically deprived CBA/CJ mice. Dose-response curves were generated for clonogenic cell survival of cells exposed to common chemotherapeutic agents; one of the lines (HEY) shows a degree of resistance to the alkylating agent cis-diamminedichloroplatinum(II) (cis-platinum). Common karyological features included structural abnormalities of chromosomes 3 and 11. Heterogeneity of expression of ovarian tumor-associated antigens was documented.
1 Supported by grants from the National Cancer Institute of Canada (R. N. B.) and by Department of Health and Human Services Grants CA 29476 and CA17094 from the National Cancer Institute (J. M. T.).
2 To whom requests for reprints should be addressed.
3 Scholar of the Leukemia Society of America.
Received 6/25/84. Revised 4/ 2/85. Accepted 4/17/85.
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