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Characterization of Effector Cells Mediating Antitumor Activity in Spleen Cells of Tumor-bearing Mice

Department of Pathology, Yamagata University School of Medicine, Iida, Zao, Yamagata 900-23, Japan

Antitumor activity of spleen cells from BALB/c mice bearing RL1 lymphoma was studied. In the Winn assay spleen cells of the tumor-bearing mice inhibited the growth of RL1 lymphoma. This antitumor activity of spleen cells was not detected by the in vitro cell-mediated cytotoxicity assay (4-h ⁵¹Cr release assay). The effector cells in spleen cells were T-cells which manifested asialo GM1 on their cell surfaces and were radiosensitive (1000 rads). The analysis of T-cell subsets using Lyt markers showed that the effector cells expressed the Lyt-2 antigen with a small amount of the Lyt-1 antigen on their cell surfaces. In addition antitumor activity of spleen cells of the tumor-bearing mice was weak in the early stage of tumor growth, strong in the mid-stage, and disappeared in the late stage. The mechanisms of antitumor activity of spleen cells of the tumor-bearing mice are discussed.

Received 2/11/85. Revised 5/29/85. Accepted 6/ 3/85.