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Enhanced Replication of Murine Cytomegalovirus in Murine Leukemic Lymphocytes¹

Division of Pediatrics, City of Hope Medical Center, Duarte, California 91010 [R. P., I. R. P., D. J. L.], and Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 22710 [R. P., K-S. C., D. J. L.]

Replication in vitro of murine cytomegalovirus was found to be enhanced in lymphoid cells from leukemic (AKR/J) mice as compared with similar cells from nonleukemic animals. Prolonged productive murine cytomegalovirus infection in lymphoid organs in vivo was demonstrable only in leukemic AKR/J mice. Latent nonproductive murine cytomegalovirus infection established in young nonleukemic AKR/J mice was invariably reactivated and expressed in salivary glands and lymphoid organs after these animals became leukemic.

¹ Part of this work was supported by Public Health Service Grant CA 09111 from The National Cancer Institute, Institutional Research Grant from City of Hope Medical Center and American Cancer Society Grant BC-390.

Received 7/16/85. Revised 9/23/85. Accepted 9/25/85.

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