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Selective Cytotoxicity of Calmidazolium and Trifluoperazine for Cycling versus Noncycling C3H10T Cells in Vitro¹

Medical Biophysics Branch, Atomic Energy of Canada Limited Research Company, Whiteshell Nuclear Research Establishment, Pinawa, Manitoba, Canada R0E 1L0 [J. B., M. E., M. D. S.], and Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W0 [R. A. H.]

Effects of two anticalmodulin drugs, trifluoperazine and calmidazolium, on normal and transformed C3H10T cells were examined in vitro. As indicated by reduction of plating efficiencies in the presence of these drugs, the intrinsic sensitivities of normal and transformed cells were similar and showed no consistent differences. Comparison of cell killing kinetics in cycling and noncycling cell populations revealed that both drugs were preferentially cytotoxic for cycling cells. This differential cytotoxicity for cycling versus noncycling cells could provide a basis for exploitation of anticalmodulin drugs in cancer chemotherapy.

¹ Supported by Atomic Energy of Canada Limited Research Company.

² To whom requests for reprints should be addressed.

Received 10/31/84. Revised 5/23/85. Accepted 9/30/85.