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Detection of a Polyoma Virus-induced Tumor-associated Membrane Antigen in Mouse Cells by the Macrophage Migration Inhibition Test¹

Department of Tumor Biology, Karolinska Institute, Box 60400, 104 01 Stockholm [T. R., G. K., R. S.], and The Stockholm County Council, Central Microbiological Laboratory, P. O. Box 177, 101 22 Stockholm [T. D., G. R.], Sweden

Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with polyoma cells, but not with nonpolyoma cell lines, abrogates this activity. These findings suggest that there is a polyoma virus-induced membrane component that can induce polyoma-specific macrophage migration inhibition.

¹ This work was supported by Grant 3 R01 CA14054-12S1 awarded by the National Cancer Institute, Department of Health and Human Services, and by the Swedish Cancer Society.

² To whom requests for reprints should be addressed.

³ Recipient of a fellowship from the Cancer Research Institute and Concern Foundation.

⁴ Recipient of a research fellowship from the Swedish Cancer Society.

Received 3/ 3/86. Revised 6/ 7/86. Accepted 6/18/86.