This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chelmicka-Schorr, E. Articles by Arnason, B. G. W. Search for Related Content PubMed PubMed Citation Articles by Chelmicka-Schorr, E. Articles by Arnason, B. G. W.

Sympathetic Nervous System Trophism for Neuroblastoma and Its Age Dependence in Rats¹

Departments of Neurology [E. C-S., M. E. C., K. H. J., R. C. Y., B. G. W. A.] and Pediatrics [E. C-S.] and The Brain Research Institute, The University of Chicago, Chicago, Illinois 60637

The sympathetic nervous system modulates the growth of C-1300 mouse neuroblastoma in vivo and in vitro. We now report that a mitogenic/trophic factor that augments growth of C-1300 neuroblastoma and of the S-20 neuroblastoma clonal line is present in freshly excised sympathetic cervical ganglia from newborn rats, but is not detectable in homogenates from sympathetic ganglia obtained from adult rats.

¹ This work was supported in part by Grant 5R01 NS-18413-02 from the NIH and by the Sarah D. Mayer Memorial Grant for Cancer Research of the American Cancer Society, PDT-253.

² To whom requests for reprints should be addressed, at Department of Neurology, BH Box 425, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637.

Received 12/10/85. Revised 4/23/86. Revised 7/29/86. Accepted 7/31/86.

This article has been cited by other articles:

				N. F. Schor Neuroblastoma: A Neurochemical Approach J Child Neurol, July 1, 1991; 6(3): 220 - 228. [Abstract] [PDF]