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Photosensitization of Leukemia L1210 Cells with Diaziquone¹

Departments of Medicine (Oncology) and Pharmacology, Wayne State University School of Medicine, and Harper-Grace Hospitals, Detroit, Michigan 48201

Exposure of leukemia L1210 cells in culture to the drug diaziquone resulted in inhibition of incorporation of labeled thymidine into nucleic acid and loss of cell viability. These effects were markedly potentiated by irradiation of cells previously exposed to diaziquone in culture. This result shows that diaziquone can catalyze phototoxicity; the action spectrum of the drug may limit clinical applications of this phenomenon.

¹ Supported in part by Grant CA 23378 from the National Cancer Institute, NIH, Department of Health and Human Services.

² To whom requests for reprints should be addressed, at the Department of Medicine, Harper-Grace Hospitals, Detroit, MI 48201.

Received 4/30/86. Revised 7/29/86. Accepted 8/ 5/86.