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Identification and Quantitative Determination of Aniline and Toluidines in Human Urine¹

Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595

Aniline and o-, m-, and p-toluidine, which are representative of aromatic amines in cigarette smoke, were identified and quantified in human urine. Smokers excreted 3.1 ± 2.6 µg/24 h of aniline and 6.3 ± 3.7 µg/24 h of o-toluidine (n = 16). Nonsmokers excreted 2.8 ± 2.5 µg/24 h of aniline and 4.1 ± 3.2 µg/24 h of o-toluidine (n = 12). Meta- and p-toluidine were detected in the urine of 2 of 11 smokers and 4 of 9 nonsmokers. The observed intra- and interindividual variations in the amounts of urinary aniline and o-toluidine were relatively large. The results of this study demonstrate for the first time that aniline and toluidines are present in human urine and suggest that sources other than cigarette smoke contribute significantly to their concentrations in urine.

¹ This study was supported by National Cancer Institute Grant CA-29580. This is Paper No. XXXIII in the series, "A Study of Tobacco Carcinogenesis."

² To whom requests for reprints should be addressed.

Received 3/31/86. Revised 6/30/86. Accepted 7/31/86.